HCID 59558650, compound → tert-Butyl 7,9-dioxo-2,6-diazaspiro[3.5]nonane-2-carboxylate

HRID 1175156Notes

Reaction equation

HRID 1175156 reaction equation
COC([CH:5]1[C:20](=[O:21])[C:9]2([CH2:12][N:11]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:10]2)[CH2:8][NH:7][C:6]1=[O:22])=O>C(#N)C.O>[C:16]([O:15][C:13]([N:11]1[CH2:12][C:9]2([C:20](=[O:21])[CH2:5][C:6](=[O:22])[NH:7][CH2:8]2)[CH2:10]1)=[O:14])([CH3:19])([CH3:17])[CH3:18]

Participants

3

Reactant 1

HCID 59558650HCID 59558650, compound

Product 1

HCID 57415907tert-Butyl 7,9-dioxo-2,6-diazaspiro[3.5]nonane-2-carboxylate

Reagents, catalysts & solvents 1

HCID 18373917Acetonitrile--water (1/1)Solvent

Procedure

7,9-Dioxo-2,6-diaza-spiro[3.5]nonane-2,8-dicarboxylic acid 2-tert-butyl ester 8-methyl ester (Example 156g)(8.3 g; 26.6 mmol) is dissolved in acetonitrile/water (170 ml; 9/1) and refluxed for 1 hour. The reaction mixture is evaporated to dryness and delivers the title compound as white crystals (6.35 g; 94%).

Workup

  1. temperaturerefluxed for 1 hour
  2. customThe reaction mixture is evaporated to dryness

Sources & evidence

ORD record
ord-0b85973da25747c8bc0e765af33525bc
Source dataset
uspto-grants-2010_11
Patent number
US07838674B2

Reaction notes

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