反应详情

1-[(2-Methoxycarbonyl-acetylamino)-methyl]-cyclobutanecarboxylic acid ethyl ester (1.62 g, 6.3 mmol) dissolved in 15 ml toluene is added dropwise to a freshly prepared solution of sodium (0.15 g, 6.5 mmol) in methanol (20 ml). The reaction mixture is refluxed for 3 hours and then extracted 3 times with water. The aqueous phase is acidified using HClconc. and the now acidic solution is extracted with ethyl acetate. Drying and evaporation of the solvent delivered the crude product which is used in the next step without further purification.

1. temperatureThe reaction mixture is refluxed for 3 hours
2. extractionextracted 3 times with water
3. extractionand the now acidic solution is extracted with ethyl acetate
4. customDrying
5. customevaporation of the solvent
6. customis used in the next step without further purification