反应详情

Acetic anhydride (0.78 mL) was added to a mixture of N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-methoxypyrimidin-4-yl]piperazine-1-sulfonamide, trifluoroacetate salt (the title product of Example 36, 0.84 g) and N,N-diisopropylethylamine (1 mL) in DCM (5 mL). The reaction mixture was stirred at room temperature for 30 min and the solvent evaporated under reduced pressure. The residue was dissolved in EtOAc which was washed with aqueous citric acid, H2O, dried (MgSO4) and the solvent evaporated under reduced pressure. The residue was purified by flash chromatography on silica gel, eluting with EtOAc to give the title compound as a white solid. Yield: 78 mg.

1. customthe solvent evaporated under reduced pressure
2. dissolutionThe residue was dissolved in EtOAc which
3. washwas washed with aqueous citric acid, H2O
4. dry with materialdried (MgSO4)
5. customthe solvent evaporated under reduced pressure
6. customThe residue was purified by flash chromatography on silica gel
7. washeluting with EtOAc