Methanesulfonamide → HCID 59558824, compound

HRID 1175400Notes

Reaction equation

HRID 1175400 reaction equation
[CH3:1][S:2]([NH2:5])(=[O:4])=[O:3].Cl[C:7]1[CH:12]=[C:11]([O:13][CH3:14])[N:10]=[C:9]([S:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:18]=2[F:24])[N:8]=1>>[F:24][C:18]1[C:19]([F:23])=[CH:20][CH:21]=[CH:22][C:17]=1[CH2:16][S:15][C:9]1[N:8]=[C:7]([NH:5][S:2]([CH3:1])(=[O:4])=[O:3])[CH:12]=[C:11]([O:13][CH3:14])[N:10]=1

Participants

3

Reactant 2

HCID 72879MethanesulfonamideHCID 866198774-Chloro-2-([(2,3-difluorophenyl)methyl]thio]-6-methoxypyrimidine2×

Product 1

HCID 59558824HCID 59558824, compound

Procedure

The title compound was prepared from methane sulfonamide (0.11 g) and 4-Chloro-2-[[(2,3-difluorophenyl)methyl]thio]-6-methoxypyrimidine (the product of Example 35, step i) (0.25 g) according to the procedure outlined in Example 1, step iv). The crude material was purified by column chromatography using EtOAc/isohexane (2:8) as eluent. Yield: 0.12 g.

Workup

  1. customThe crude material was purified by column chromatography

Sources & evidence

ORD record
ord-ce5896d32854479e97637f14e0265c09
Source dataset
uspto-grants-2010_11
Patent number
US07838675B2

Reaction notes

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