N-(tert-butyl)-5-cyanofuran-2-sulfonamide → 5-Cyanofuran-2-sulfonamide

HRID 1175428Notes

Reaction equation

HRID 1175428 reaction equation
C([NH:5][S:6]([C:9]1[O:10][C:11]([C:14]#[N:15])=[CH:12][CH:13]=1)(=[O:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[C:14]([C:11]1[O:10][C:9]([S:6]([NH2:5])(=[O:8])=[O:7])=[CH:13][CH:12]=1)#[N:15]

Participants

3

Reactant 1

HCID 53628367N-(tert-butyl)-5-cyanofuran-2-sulfonamide

Product 1

HCID 536283695-Cyanofuran-2-sulfonamide

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of N-(tert-butyl)-5-cyanofuran-2-sulfonamide (the product of example 50, step i) (1.0 g) in trifluoroacetic acid (300 mL) was stirred at room temperature for 24 h. The mixture was evaporated to dryness in vacuo to leave a crude yellow oil that was triturated with Et2O and filtered. The filtrate was evaporated to dryness in vacuo to give the subtitle compound as a pale yellow oil. Yield: 0.29 g.

Workup

  1. customThe mixture was evaporated to dryness in vacuo
  2. customto leave a crude yellow oil that
  3. customwas triturated with Et2O
  4. filtrationfiltered
  5. customThe filtrate was evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-9977a721b955460186cc2ba04c48489f
Source dataset
uspto-grants-2010_11
Patent number
US07838675B2

Reaction notes

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