HCID 86619885, compound → 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide

HRID 1175473Notes

Reaction equation

HRID 1175473 reaction equation
C([NH:5][S:6]([C:9]1[CH:18]=[C:17]2[C:12]([CH2:13][CH2:14][N:15](C(=O)C(F)(F)F)[CH2:16]2)=[CH:11][CH:10]=1)(=[O:8])=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O>[CH2:16]1[C:17]2[C:12](=[CH:11][CH:10]=[C:9]([S:6]([NH2:5])(=[O:7])=[O:8])[CH:18]=2)[CH2:13][CH2:14][NH:15]1

Participants

3

Reactant 1

HCID 86619885HCID 86619885, compound2×

Product 1

HCID 52261,2,3,4-tetrahydroisoquinoline-7-sulfonamide

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

N-(tert-Butyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (the product from step i), 1.78 g) was dissolved in TFA and stirred at room temperature for 96 h. The reaction was reduced in vacuo and the residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane to give the subtitle compound as a white solid. Yield: 0.65 g

Workup

  1. customthe residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane

Sources & evidence

ORD record
ord-0520002448ed40f19db55497713bce3f
Source dataset
uspto-grants-2010_11
Patent number
US07838675B2

Reaction notes

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