反应详情

A solution of tert-Butyl 4-[({2-[(2,3-difluorobenzyl)thio]-6-methoxypyrimidin-4-yl}amino)sulfonyl]-1,4-diazepane-1-carboxylate (the product of step i, 0.22 g) in 1:1 TFA:methanol (6 ml) was stirred at room temperature for 3 h then the volatiles evaporated and 7M ammonia in methanol (5 ml) added to the residue. The solution was stirred for 30 min then the volatiles evaporated and the resulting solid washed with methanol, DCM, dimethyl sulfoxide and H2O to afford the title compound as a white powder. Yield: δ 1 mg

1. customthe volatiles evaporated
2. addition7M ammonia in methanol (5 ml) added to the residue
3. customthe volatiles evaporated
4. washthe resulting solid washed with methanol, DCM, dimethyl sulfoxide and H2O