3-Cyanophenylboronic acid → HCID 58789425, 화합물

HRID 1175572노트

반응식

HRID 1175572 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:17])([CH3:16])[C:9]([NH:11][CH2:12][CH:13]([CH3:15])[CH3:14])=[O:10])=[CH:4][CH:3]=1.[C:18]([C:20]1[CH:21]=[C:22](B(O)O)[CH:23]=[CH:24][CH:25]=1)#[N:19]>>[C:18]([C:20]1[CH:25]=[C:24]([C:2]2[CH:7]=[CH:6][C:5]([C:8]([CH3:17])([CH3:16])[C:9]([NH:11][CH2:12][CH:13]([CH3:15])[CH3:14])=[O:10])=[CH:4][CH:3]=2)[CH:23]=[CH:22][CH:21]=1)#[N:19]

참가 물질

3

반응물 2

HCID 27343253-Cyanophenylboronic acidHCID 687750752-(4-Bromophenyl)-N-isobutyl-2-methylpropanamide

생성물 1

HCID 58789425HCID 58789425, 화합물수율 63%

실험 절차

Prepared in a similar manner to example 8 from 2-(4-Bromophenyl)-N-isobutyl-2-methylpropanamide (Example 1a) and 3-cyanophenylboronic acid. Yield: 63%. 1H NMR (400 MHz, CDCl3): δ 0.8 (d, 6H), 1.65 (s, 6H), 1.67-1.70 (m,1H), 3 (dd, 2H), 5.2 (broad, 1H), 7.45 (d, 2H), 7.55 (d, 3H), 7.65 (d, 1H), 8.2 (dd, 1H), 8.4 (d, 1H). MS (M+H, 321).

출처 및 근거

ORD 기록
ord-b2ab7ce4b2984289b8c93f450c146fab
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07842324B2

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