Isobutylamine → HCID 58789413, compound

HRID 1175589Notes

Reaction equation

HRID 1175589 reaction equation
[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([CH:7]([NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[C:8]([OH:10])=O)=[CH:3][CH:2]=1.[CH2:25]([NH2:29])[CH:26]([CH3:28])[CH3:27]>>[C:1]1([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:6]=[CH:5][C:4]([CH:7]([NH:11][C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[C:8]([NH:29][CH2:25][CH:26]([CH3:28])[CH3:27])=[O:10])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 6558IsobutylamineHCID 18770129([1,1'-Biphenyl]-4-yl)[(tert-butoxycarbonyl)amino]acetic acid

Product 1

HCID 58789413HCID 58789413, compoundYield 55%

Procedure

Prepared in a similar manner to Example 20 from 2-(biphenyl-4-yl)-2-(tert-butoxycarbonylamino)acetic acid and isobutyl amine. Yield: 55%. 1H NMR (400 MHz, dMSO): δ 0.76-0.78 (d, 6H), 1.38 (s, 9H), 1.63-1.66 (m, 1H), 2.84-2.92 (m, 2H), 5.30-5.22 (d, 1H), 7.25-7.27 (d, 1H), 7.35-7.37 (m, 1H), 7.43-7.51 (m, 4H), 7.61-7.66 (m, 4H), 8.14-8.17 (t, 1H); MS+H (383).

Sources & evidence

ORD record
ord-966dfc33799141b1a424bfca06389b6f
Source dataset
uspto-grants-2010_11
Patent number
US07842324B2

Reaction notes

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