HCID 25005299, compound → HCID 25006013, compound

HRID 1175675Notes

Reaction equation

HRID 1175675 reaction equation
[O:1]=[C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][N:3]1[C@@H:9]1[O:13][C@:12]([CH3:24])([O:14][CH2:15][P:16](=[O:23])([O:20]CC)[O:17]CC)[C@@H:11]([OH:25])[C@H:10]1[OH:26].NC1N=CN=C2C=1N=CN2[C@@H]1O[C@](C)(OCP(=O)(O)O)[C@@H](O)[C@H]1O>>[O:1]=[C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][N:3]1[C@@H:9]1[O:13][C@:12]([CH3:24])([O:14][CH2:15][P:16](=[O:17])([OH:23])[OH:20])[C@@H:11]([OH:25])[C@H:10]1[OH:26]

Participants

3

Reactant 2

HCID 25005299HCID 25005299, compoundHCID 25006015HCID 25006015, compound

Product 1

HCID 25006013HCID 25006013, compoundYield 75.2%

Procedure

Compound 32.4 (61 mg, 75% yield) was synthesized from compound 32.2 (95 mg, 0.24 mmol) using the procedure described for the preparation of compound 31.5. 1H NMR (300 MHz, D2O) δ 1.38 (s, 3H), 3.50 (m, 2H), 3.98 (d, 1H, J=4.6), 5.84 (d, 1H, J=7.6), 6.08 (d, 1H, J=7.3), 7.81 (d, 1H, J=8.2). LRMS [M-H]− C10H15N2O9P requires 337.2. Found 337.2.

Sources & evidence

ORD record
ord-30bd402fc988464a93d492c04fe6759c
Source dataset
uspto-grants-2010_11
Patent number
US07842672B2

Reaction notes

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