Potassium Nitrate → 8-Chloro-5-nitroisoquinoline

HRID 1175749Notes

Reaction equation

HRID 1175749 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[CH:10]=[N:9][CH:8]=[CH:7]2.[N+:12]([O-])([O-:14])=[O:13].[K+]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:12]([O-:14])=[O:13])=[C:6]2[C:11]=1[CH:10]=[N:9][CH:8]=[CH:7]2

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 6409548-chloroisoquinoline

Product 1

HCID 534208768-Chloro-5-nitroisoquinoline

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

To a solution of 8-chloroisoquinoline (1 mmol) in concentrated sulfuric acid at 0° C. was added potassium nitrate (1.1 mmol). The reaction mixture was warmed to room temperature and stirred at room temperature for 5 hours. The reaction mixture was basified Solid precipitated was column purified to afford a pale yellow solid.

Workup

  1. customprecipitated
  2. custompurified
  3. customto afford a pale yellow solid

Sources & evidence

ORD record
ord-2e630a2f56314203904bad44784061a0
Source dataset
uspto-grants-2010_11
Patent number
US07842703B2

Reaction notes

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