Potassium Nitrate → 8-Chloro-5-nitroisoquinoline

Participants

Reaction Steps

To a solution of 8-chloroisoquinoline (1 mmol) in concentrated sulfuric acid at 0° C. was added potassium nitrate (1.1 mmol). The reaction mixture was warmed to room temperature and stirred at room temperature for 5 hours. The reaction mixture was basified Solid precipitated was column purified to afford a pale yellow solid.

Provenance & Evidence