1-methyl-5-nitroIsoquinoline → 1-Methylisoquinolin-5-amine

HRID 1175752Notes

Reaction equation

HRID 1175752 reaction equation
[CH3:1][C:2]1[C:11]2[C:6](=[C:7]([N+:12]([O-])=O)[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1>C(O)C.[C].[Pd]>[CH3:1][C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([NH2:12])[C:6]=2[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 1

HCID 126479501-methyl-5-nitroIsoquinoline

Product 1

HCID 99894901-Methylisoquinolin-5-amine

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A solution of 1-methyl-5-nitroisoquinoline in ethanol was hydrogenated in the presence of 10% palladium carbon at 60 psi for 4 hours. Reaction mixture was filtered through celite bed. Filtrate was concentrated under vacuum to afford the desired compound as pale white solid.

Workup

  1. customReaction mixture
  2. filtrationwas filtered through celite bed
  3. concentrationFiltrate was concentrated under vacuum

Sources & evidence

ORD record
ord-fac70d2e79b64374ba940d6ce0e8761d
Source dataset
uspto-grants-2010_11
Patent number
US07842703B2

Reaction notes

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