Ammonia → HCID 135599896, compound

HRID 1175826Notes

Reaction equation

HRID 1175826 reaction equation
[NH2:1][C:2]1[N:3]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[CH3:32])[N:4]=[C:5]2[C:14]3[C:13]([O:15][CH2:16][CH2:17][CH2:18][C:19](OC)=[O:20])=[CH:12][C:11]([O:23][CH3:24])=[CH:10][C:9]=3[NH:8][C:7](=[O:25])[C:6]=12.[NH3:33]>CO>[NH2:1][C:2]1[N:3]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[CH3:32])[N:4]=[C:5]2[C:14]3[C:13]([O:15][CH2:16][CH2:17][CH2:18][C:19]([NH2:33])=[O:20])=[CH:12][C:11]([O:23][CH3:24])=[CH:10][C:9]=3[NH:8][C:7](=[O:25])[C:6]=12

Participants

4

Reactant 2

HCID 222AmmoniaHCID 135599995HCID 135599995, compound

Product 1

HCID 135599896HCID 135599896, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of methyl 4-{[3-amino-7-methoxy-2-(2-methylphenyl)-4-oxo-4,5-dihydro-2H-pyrazolo[4,3-c]quinolin-9-yl]oxy}butanoate (60 mg) and 2N solution of ammonia in methanol was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified with column chromatography to obtain the target compound (37 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified with column chromatography

Sources & evidence

ORD record
ord-65e7bef094d64c478a84671caffb4fd9
Source dataset
uspto-grants-2010_11
Patent number
US07842701B2

Reaction notes

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