Tetrahydrofuran → HCID 178526743, compound

HRID 1176050Notes

Reaction equation

HRID 1176050 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([Cl:11])[N:5]=[CH:4][N:3]=1.[NH2:12][C:13]1[CH:17]=[CH:16][NH:15][N:14]=1.[CH2:18]1[CH2:22]OC[CH2:19]1>>[Cl:11][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:12][C:13]2[NH:14][N:15]=[C:16]([CH:19]3[CH2:18][CH2:22]3)[CH:17]=2)[C:7]=1[N+:8]([O-:10])=[O:9]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 203124,6-Dichloro-5-nitropyrimidineHCID 178418806HCID 178418806, compound

Product 1

HCID 178526743HCID 178526743, compound

Procedure

To a solution of 4,6-dichloro-5-nitro-pyrimidine (100 mg, 0.52 mmol) in anhydrous THF (2 mL) was added aminopyrazole (76 mg, 0.62 mmol). The solution was stirred at RT for 2 hrs and was filtered via short silica gel column. The filtrate that contained product and the unreacted starting pyrimidine was concentrated under vacuum. The resulting residue was used directly without further purification.

Workup

  1. filtrationwas filtered via short silica gel column
  2. concentrationwas concentrated under vacuum
  3. customThe resulting residue was used directly without further purification

Sources & evidence

ORD record
ord-4b19ae1cde81476e9cc43453b07c8528
Source dataset
uspto-grants-2010_11
Patent number
US07842712B2

Reaction notes

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