反应详情

To a solution of 4-bromobenzoyl chloride (2.2 g, 10 mmol) and pyridine (1 mLl) in CH2Cl2 at 0° C. is added 3-(dimethylamino)pyrrolidine (1.14 mL, 10 mmol). The reaction is stirred at room temperature for 2 h, diluted with ether and filtered. The filtercake is washed with ether, treated with 0.1 N sodium hydroxide, stirred and filtered. This filtercake is washed with ether and recrystallized from petroleum ether to give 1-(4-bromobenzoyl)-3-dimethylaminopyrrolidine as a white powder (1.5 g), identified by NMR analysis.

1. filtrationfiltered
2. washThe filtercake is washed with ether
3. additiontreated with 0.1 N sodium hydroxide
4. stirringstirred
5. filtrationfiltered
6. washThis filtercake is washed with ether
7. customrecrystallized from petroleum ether