Benzyl formate → HCID 68502032, compound

HRID 1176284Notes

Reaction equation

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH:9]2[O:14][CH2:15][C:16]2[CH:25]=[C:24]3[C:19]([CH2:20][CH2:21][C:22](=[O:31])[N:23]3[CH2:26][CH2:27][CH2:28][O:29][CH3:30])=[CH:18][CH:17]=2)=[CH:4][CH:3]=1.[CH:32]([O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:33]>>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][N:11]([C:32]([O:34][CH2:35][C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)=[O:33])[CH2:10][CH:9]2[O:14][CH2:15][C:16]2[CH:25]=[C:24]3[C:19]([CH2:20][CH2:21][C:22](=[O:31])[N:23]3[CH2:26][CH2:27][CH2:28][O:29][CH3:30])=[CH:18][CH:17]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7708Benzyl formate

HCID 68504377HCID 68504377, compound

Product 1

HCID 68502032HCID 68502032, compound

Procedure

Analogously to Example 10f, 0.190 g of 7-[4-(4-hydroxyphenyl)piperidin-3-yloxymethyl]-1-(3-methoxypropyl)-3,4-dihydro-1H-quinolin-2-one and 0.070 ml of benzyl formate are reacted. The title compound is obtained as a white foam. Rf=0.19 (2:1 EtOAc-heptane); Rt=6.03.

Sources & evidence

ORD record: ord-20e1dced9afa4ae18d621e89fb2a517f
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07842688B2

Reaction notes

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