HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-(4-allyloxyphenyl)-3-hydroxypiperidine-1-carboxylate → tert-Butyl 4-(4-allyloxyphenyl)-3-[1-(3-methoxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethoxy]piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-(4-allyloxyphenyl)-3-hydroxypiperidine-1-carboxylate | HCID 54331732 | — |
| Reactant | 7-chloromethyl-1-(3-methoxypropyl)-3,4-dihydro-1H-quinolin-2-one | HCID 68504434 | — |
| Product | tert-Butyl 4-(4-allyloxyphenyl)-3-[1-(3-methoxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethoxy]piperidine-1-carboxylate | HCID 68497775 | — |
Reaction Steps
Analogously to Method D, 3.26 g of tert-butyl 4-(4-allyloxyphenyl)-3-hydroxypiperidine-1-carboxylate and 2.62 g of 7-chloromethyl-1-(3-methoxypropyl)-3,4-dihydro-1H-quinolin-2-one are reacted. The title compound is obtained as a slightly yellowish oil. Rf=0.16 (1:1 EtOAc-heptane); Rt=5.50.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842688B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-c57ef5d169e948e9a10ea12be96e6cb7 |
| Source note | uspto-grants-2010_11 |