2-(3-Bromopropoxy)-1-methoxy-3-methylbenzene → HCID 68503836, compound

HRID 1176347Notes

Reaction equation

HRID 1176347 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH:9]2[O:21][CH2:22][C:23]2[CH:32]=[C:31]3[C:26]([CH2:27][CH2:28][C:29](=[O:38])[N:30]3[CH2:33][CH2:34][CH2:35][O:36][CH3:37])=[CH:25][CH:24]=2)=[CH:4][CH:3]=1.Br[CH2:40][CH2:41][CH2:42][O:43][C:44]1[C:49]([CH3:50])=[CH:48][CH:47]=[CH:46][C:45]=1[O:51][CH3:52]>>[CH3:52][O:51][C:45]1[CH:46]=[CH:47][CH:48]=[C:49]([CH3:50])[C:44]=1[O:43][CH2:42][CH2:41][CH2:40][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:19])([CH3:20])[CH3:18])=[O:15])[CH2:10][CH:9]2[O:21][CH2:22][C:23]2[CH:32]=[C:31]3[C:26]([CH2:27][CH2:28][C:29](=[O:38])[N:30]3[CH2:33][CH2:34][CH2:35][O:36][CH3:37])=[CH:25][CH:24]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 538466042-(3-Bromopropoxy)-1-methoxy-3-methylbenzeneHCID 68501561Tert-butyl 4-(4-hydroxyphenyl)-3-[1-(3-methoxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethoxy]piperidine-1-carboxylate

Product 1

HCID 68503836HCID 68503836, compound

Procedure

Analogously to Method I, 0.100 g of tert-butyl 4-(4-hydroxyphenyl)-3-[1-(3-methoxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethoxy]piperidine-1-carboxylate (Example 44d) and 0.065 g of 2-(3-bromopropoxy)-1-methoxy-3-methylbenzene are used to prepare the title compound. Rf=0.26 (2:1 EtOAc-heptane); Rt=6.05.

Sources & evidence

ORD record
ord-9391f2d6d4ce450abe297cfc666af6dd
Source dataset
uspto-grants-2010_11
Patent number
US07842688B2

Reaction notes

Loading…