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1-(4-Bromobutoxy)-3-chlorobenzene → tert-Butyl 4-{4-[4-(3-chlorophenoxy)butoxy]phenyl}-3-[1-(3-methoxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethoxy]piperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(4-Bromobutoxy)-3-chlorobenzene | HCID 2734911 | — |
| 反応物 | Tert-butyl 4-(4-hydroxyphenyl)-3-[1-(3-methoxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethoxy]piperidine-1-carboxylate | HCID 68501561 | — |
| 生成物 | tert-Butyl 4-{4-[4-(3-chlorophenoxy)butoxy]phenyl}-3-[1-(3-methoxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethoxy]piperidine-1-carboxylate | HCID 68504381 | — |
反応手順
Analogously to Method I, 0.100 g of tert-butyl 4-(4-hydroxyphenyl)-3-[1-(3-methoxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethoxy]piperidine-1-carboxylate (Example 44d) and 0.065 g of 1-(4-bromobutoxy)-3-chlorobenzene are used to prepare the title compound. Rf=0.29 (2:1 EtOAc-heptane); Rt=6.16.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07842688B2 |
| 出典データセット | uspto-grants-2010_11 |
| ORD ID | ord-d18b32c4dbec43cc997b36031d70f445 |
| 出典メモ | uspto-grants-2010_11 |