HRID1176358

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID62325

2-Methylpropanoyl chloride

C4H7ClO

结构：COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCc2ccc(Br)c(N)c2)cc1

HCID68504899

未命名化合物

PRODUCTS

生成物

结构：COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCc2ccc(Br)c(NC(=O)C(C)C)c2)cc1

HCID68500125

未命名化合物

PROCEDURE

实验过程

Analogously to Example 18e, 4.30 g of tert-butyl 3-(3-amino-4-bromobenzyloxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate are reacted with 0.78 ml of isobutyryl chloride. The title compound is obtained as a colourless oil. Rt=6.12.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d71c892f38ae4574aaca46758332c818
来源数据集: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07842688B2
来源说明: uspto-grants-2010_11

反应 SMILES

[NH2:1][C:2]1[CH:3]=[C:4]([CH:40]=[CH:41][C:42]=1[Br:43])[CH2:5][O:6][CH:7]1[CH:12]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][O:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[O:31][CH3:32])=[CH:15][CH:14]=2)[CH2:11][CH2:10][N:9]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:8]1.[C:44](Cl)(=[O:48])[CH:45]([CH3:47])[CH3:46]>>[Br:43][C:42]1[CH:41]=[CH:40][C:4]([CH2:5][O:6][CH:7]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][O:23][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=4[O:31][CH3:32])=[CH:15][CH:14]=3)[CH2:11][CH2:10][N:9]([C:33]([O:35][C:36]([CH3:39])([CH3:37])[CH3:38])=[O:34])[CH2:8]2)=[CH:3][C:2]=1[NH:1][C:44](=[O:48])[CH:45]([CH3:47])[CH3:46]