2-Methoxyethylamine → HCID 68503009, compound

HRID 1176375Notes

Reaction equation

Cl[C:2]([C:4]1[CH:5]=[C:6]([CH:42]=[CH:43][CH:44]=1)[CH2:7][O:8][CH:9]1[CH:14]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][CH2:24][O:25][CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[O:33][CH3:34])=[CH:17][CH:16]=2)[CH2:13][CH2:12][N:11]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:10]1)=[O:3].[CH3:45][O:46][CH2:47][CH2:48][NH2:49]>>[CH3:34][O:33][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=1[CH2:26][O:25][CH2:24][CH2:23][CH2:22][O:21][C:18]1[CH:19]=[CH:20][C:15]([CH:14]2[CH2:13][CH2:12][N:11]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:10][CH:9]2[O:8][CH2:7][C:6]2[CH:42]=[CH:43][CH:44]=[C:4]([C:2](=[O:3])[NH:49][CH2:48][CH2:47][O:46][CH3:45])[CH:5]=2)=[CH:16][CH:17]=1

Participants

Reactant 2

HCID 80182-Methoxyethylamine

HCID 86610001HCID 86610001, compound

Product 1

HCID 68503009HCID 68503009, compound

Procedure

Analogously to Example 127a, 0.355 g of tert-butyl 3-(3-chlorocarbonylbenzyloxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate (Example 106b) and 0.087 g of 2-methoxyethylamine are reacted. The title compound is obtained as a colourless oil. Rf=0.10 (1:1 EtOAc-heptane); Rt=5.51.

Sources & evidence

ORD record: ord-b155e46011814602bdd61a4ee67e9d38
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07842688B2

Reaction notes

Loading…