1,3-Dibromopropane → 1-(3-Bromopropoxy)-2,3-difluorobenzene

HRID 1176476Notes

Reaction equation

HRID 1176476 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].[Br:10][CH2:11][CH2:12][CH2:13]Br>>[Br:10][CH2:11][CH2:12][CH2:13][O:9][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([F:8])[C:2]=1[F:1]

Participants

3

Reactant 2

HCID 80011,3-DibromopropaneHCID 808792,3-Difluorophenol

Product 1

HCID 630386791-(3-Bromopropoxy)-2,3-difluorobenzene

Procedure

Analogously to Example 91b, 2.00 g of 2,3-difluorophenol and 30.7 g of 1,3-dibromopropane are reacted. The title compound is obtained as a colourless oil. Rf=0.39 (1:10 EtOAc-heptane); Rt=4.82.

Sources & evidence

ORD record
ord-f21dc44859e641d1b096712f54018cdf
Source dataset
uspto-grants-2010_11
Patent number
US07842688B2

Reaction notes

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