Benzyl formate → Benzyl 4-(4-allyloxyphenyl)-3-hydroxypiperidine-1-carboxylate

HRID 1176495Notes

Reaction equation

[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH:12]2[OH:17])=[CH:7][CH:6]=1)[CH:2]=[CH2:3].[CH:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19]>>[CH2:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([CH:11]2[CH2:16][CH2:15][N:14]([C:18]([O:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[O:19])[CH2:13][CH:12]2[OH:17])=[CH:9][CH:10]=1)[CH:2]=[CH2:3]

Participants

Reactant 2

HCID 7708Benzyl formate

HCID 685007234-(4-Allyloxyphenyl)piperidin-3-ol

Product 1

HCID 68501269Benzyl 4-(4-allyloxyphenyl)-3-hydroxypiperidine-1-carboxylate

Procedure

Analogously to Example 10f, 29.45 g of 4-(4-allyloxyphenyl)piperidin-3-ol and 26.8 g of benzyl formate are reacted. The title compound is obtained as a white solid. Rt=4.62.

Sources & evidence

ORD record: ord-503a06ef65014e24bfb688c90ce18a34
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07842688B2

Reaction notes

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