Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 68501830, compound

HRID 1176533Notes

Reaction equation

HRID 1176533 reaction equation
[CH3:1][C:2]1([CH3:29])[C:11]2[C:6](=[C:7]([CH2:12][O:13]C3CCCCO3)[CH:8]=[CH:9][CH:10]=2)[N:5]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25])[C:4](=[O:28])[CH2:3]1.C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1>>[OH:13][CH2:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:26])([CH3:25])[CH3:27])[C:4](=[O:28])[CH2:3][C:2]2([CH3:29])[CH3:1]

Participants

3

Reactant 2

HCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 68500824HCID 68500824, compound

Product 1

HCID 68501830HCID 68501830, compound

Procedure

Analogously to Example 129c, 0.68 g of 4,4-dimethyl-8-(tetrahydropyran-2-yloxymethyl)-1-(2-trimethylsilanylethoxymethyl)-3,4-dihydro-1H-quinolin-2-one and 0.041 g of pyridinium p-toluenesulphonate are reacted. The title compound is obtained as a yellowish oil. Rf=0.55 (1:1 EtOAc-heptane); Rt=4.78.

Sources & evidence

ORD record
ord-360d01df263a4941851f9ba6d06f5fa9
Source dataset
uspto-grants-2010_11
Patent number
US07842688B2

Reaction notes

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