3,4-dihydro-2H-pyran → HCID 68499416, compound

HRID 1176535Notes

Reaction equation

HRID 1176535 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[NH:11][C:10](=[O:13])[CH2:9][C:8]2([CH3:15])[CH3:14].[O:16]1[CH:21]=[CH:20][CH2:19][CH2:18][CH2:17]1>>[CH3:14][C:8]1([CH3:15])[C:7]2[C:12](=[C:3]([CH2:2][O:1][CH:17]3[CH2:18][CH2:19][CH2:20][CH2:21][O:16]3)[CH:4]=[CH:5][CH:6]=2)[NH:11][C:10](=[O:13])[CH2:9]1

Participants

3

Reactant 2

HCID 80803,4-dihydro-2H-pyranHCID 68503853HCID 68503853, compound

Product 1

HCID 68499416HCID 68499416, compound

Procedure

Analogously to Example 129g, 2.5 g of 8-hydroxymethyl-4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one and 2.28 ml of 3,4-dihydro-2H-pyran are reacted. The title compound is obtained as a light brown oil. Rf=0.25 (1:1 EtOAc-heptane); Rt=4.28.

Sources & evidence

ORD record
ord-77a7eb89837c4c2684f052931c779001
Source dataset
uspto-grants-2010_11
Patent number
US07842688B2

Reaction notes

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