Benzyl 3-hydroxy-4-(4-hydroxyphenyl)piperidinecarboxylate → HCID 68499094, compound

HRID 1176577Notes

Reaction equation

HRID 1176577 reaction equation
[OH:1][CH:2]1[CH:7]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH2:6][CH2:5][N:4]([C:15]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:16])[CH2:3]1.C1(C)C(S(O[CH:35]2[CH2:38][N:37]([C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])[CH2:36]2)(=O)=O)=CC=CC=1>>[C:42]([O:41][C:39]([N:37]1[CH2:38][CH:35]([O:14][C:11]2[CH:10]=[CH:9][C:8]([CH:7]3[CH2:6][CH2:5][N:4]([C:15]([O:17][CH2:18][C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=4)=[O:16])[CH2:3][CH:2]3[OH:1])=[CH:13][CH:12]=2)[CH2:36]1)=[O:40])([CH3:45])([CH3:43])[CH3:44]

Participants

3

Reactant 2

HCID 68500730Benzyl 3-hydroxy-4-(4-hydroxyphenyl)piperidinecarboxylateHCID 86626135HCID 86626135, compound

Product 1

HCID 68499094HCID 68499094, compound

Procedure

Analogously to Method I, 9.170 g of benzyl 3-hydroxy-4-(4-hydroxyphenyl)piperidinecarboxylate and 11.00 g of tert-butyl 3-(toluenesulphonyloxy)azetidine-1-carboxylate are reacted. The title compound is obtained as a yellow oil. Rf=0.23 (3:1 EtOAc-heptane); Rt=5.01.

Sources & evidence

ORD record
ord-f907f71be235418e881a16fd3f496a5c
Source dataset
uspto-grants-2010_11
Patent number
US07842688B2

Reaction notes

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