Sulfuric Acid → Methyl 2-oxo-2,3,4,5-tetrahydro-1H-benz[b]azepine-9-carboxylate
Reaction equation
OS(O)(=O)=O.[O:6]=[C:7]1[C:16]2[C:15]([C:17]([O:19][CH3:20])=[O:18])=[CH:14][CH:13]=[CH:12][C:11]=2[CH2:10][CH2:9][CH2:8]1.[N-:21]=[N+]=[N-].[Na+].C(=O)([O-])[O-].[K+].[K+].[OH-].[K+]>C(Cl)(Cl)Cl.O>[O:6]=[C:7]1[NH:21][C:16]2[C:15]([C:17]([O:19][CH3:20])=[O:18])=[CH:14][CH:13]=[CH:12][C:11]=2[CH2:10][CH2:9][CH2:8]1Participants
Reactant 5
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 10 °C
Procedure
Conc. H2SO4 is added dropwise at 0° C. to a solution of 3.040 g of methyl 8-oxo-5,6,7,8-tetrahydronaphthalene-1-carboxylate in 550 ml of chloroform, in the course of which the temperature is kept at 0-3° C. On completion of addition, the reaction solution is warmed to 10° C. and 21.80 g of sodium azide are added in portions over the course of 45 minutes. The reaction mixture is subsequently stirred at 50° C. over 2.5 hours. The reaction mixture is cooled to room temperature and subsequently poured onto a mixture of 200 g of potassium carbonate, 1000 ml of water and 400 g of ice. The mixture is made basic with 44 ml of 50% KOH and extracted with 2×500 ml of dichloromethane. The combined organic phases are washed with 1000 ml of water and concentrated. The title compound is obtained as a reddish solid from the residue by means of flash chromatography (SiO2 60F). Rf=0.25 (1:1 EtOAc-heptane); Rt=3.38.
Workup
- customis kept at 0-3° C
- additionOn completion of addition
- temperatureThe reaction mixture is cooled to room temperature
- extractionextracted with 2×500 ml of dichloromethane
- washThe combined organic phases are washed with 1000 ml of water
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-7b5aca8133324ce78775c482da2f902c
- Source dataset
- uspto-grants-2010_11
- Patent number
- US07842688B2
Reaction notes
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