2-Aminobenzimidazole → HCID 11573841, compound

HRID 1176662Notes

Reaction equation

HRID 1176662 reaction equation
[NH2:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[F:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16]Br)=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][N:3]2[C:4]3[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=3[N:6]([CH2:16][C:15]3[CH:18]=[CH:19][C:12]([F:11])=[CH:13][CH:14]=3)[C:2]2=[NH:1])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 136242-AminobenzimidazoleHCID 680214-Fluorobenzyl bromide

Product 1

HCID 11573841HCID 11573841, compound

Procedure

The title compound was prepared from 2-aminobenzimidazole and 4-fluorobenzyl bromide by Procedure A. The product was isolated by preparative LCMS to give the title compound as the free base (white solid, mp 148-150° C.). MS(ES+) m/z 351 ([M+1]+, 100). 1NMR (DMSO-d6) δ 5.07 (s, 4H), 5.75 (br s, 1H), 6.78-6.91 (m, 4H), 7.12-7.18 (m, 4H), 7.30-7.42 (m, 4H).

Workup

  1. customThe product was isolated by preparative LCMS

Sources & evidence

ORD record
ord-4fce2fc7e2b54fcabc404f12fcbe0b30
Source dataset
uspto-grants-2010_11
Patent number
US07842817B2

Reaction notes

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