2-Aminobenzimidazole → HCID 11689553, compound

HRID 1176663Notes

Reaction equation

HRID 1176663 reaction equation
[NH2:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[F:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][C:19]=1[F:20])[CH2:15]Br>>[F:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][C:19]=1[F:20])[CH2:15][N:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]([CH2:15][C:14]2[CH:17]=[CH:18][C:19]([F:20])=[C:12]([F:11])[CH:13]=2)[C:2]1=[NH:1]

Participants

3

Reactant 2

HCID 136242-AminobenzimidazoleHCID 5814364-(Bromomethyl)-1,2-difluorobenzene

Product 1

HCID 11689553HCID 11689553, compound

Procedure

The title compound was prepared from 2-aminobenzimidazole and 3,4-difluorobenzyl bromide by Procedure A. The product was isolated by preparative LCMS to give the title compound as the free base (white solid, mp 114-117° C.). MS(ES+) m/z 387 ([M+1]+, 100). 1NMR (DMSO-d6) δ 5.08 (br s, 4H), 5.86 (br s, 1H), 6.72-6.96 (m, 4H), 7.05-7.22 (m, 2H), 7.35-7.45 (m, 4H).

Workup

  1. customThe product was isolated by preparative LCMS

Sources & evidence

ORD record
ord-5f6bf46f35294e288f422309808efc50
Source dataset
uspto-grants-2010_11
Patent number
US07842817B2

Reaction notes

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