2-Chlorobenzimidazole → HCID 11660993, compound

HRID 1176670Notes

Reaction equation

HRID 1176670 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[F:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][C:19]=1[F:20])[CH2:15]Br.[F:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][C:29]=1[F:30])[CH2:25][NH2:26]>>[F:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][C:19]=1[F:20])[CH2:15][N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[N:3]=[C:2]1[NH:26][CH2:25][C:24]1[CH:27]=[CH:28][C:29]([F:30])=[C:22]([F:21])[CH:23]=1

Participants

4

Reactant 3

HCID 785722-ChlorobenzimidazoleHCID 1235723,4-DifluorobenzylamineHCID 5814364-(Bromomethyl)-1,2-difluorobenzene

Product 1

HCID 11660993HCID 11660993, compound

Procedure

The title compound was prepared by Procedure B in two steps from 2-chloro-benzimidazole, 3,4-difluorobenzyl bromide and 3,4-difluorobenzylamine. The product was isolated by column chromatography to give the title compound as the free base (oil). MS(ES+) m/z 386 ([M+1]+, 100). 1NMR (DMSO-d6) δ 4.59 (d, 2H), 5.30 (s, 2H), 6.87-6.97 (m, 3H), 7.16-7.49 (m, 8H).

Workup

  1. customThe product was isolated by column chromatography

Sources & evidence

ORD record
ord-6753df362b8843f4863d8bc875ab12d0
Source dataset
uspto-grants-2010_11
Patent number
US07842817B2

Reaction notes

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