Hydrochloric Acid → 2H-1,2,4-Benzothiadiazine-3-acetic acid, 7-[(methylsulfonyl)amino]-, 1,1-dioxide
Reaction equation
C[O:2][C:3](=[O:23])[CH2:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][C:9]=1[S:19](=[O:22])(=[O:21])[NH2:20])=O.[OH-].[Na+].Cl>>[CH3:18][S:15]([NH:14][C:11]1[CH:12]=[CH:13][C:8]2[NH:7][C:5]([CH2:4][C:3]([OH:2])=[O:23])=[N:20][S:19](=[O:22])(=[O:21])[C:9]=2[CH:10]=1)(=[O:17])=[O:16]Participants
Conditions
- Temperature
- 100 °C
Procedure
N-(4-Methanesulfonylamino-2-sulfamoylphenyl)-malonamic acid methyl ester (Example 17f, 21.75 g, 59.53 mmol) was dissolved in an aqueous solution of sodium hydroxide (7.14 g, 178.5 mmol; dissolved in 180 mL water) at 25° C. The reaction mixture was heated to 100° C. for 1 h, then was gradually cooled over 30 min to 0° C. 12.0 M Aqueous hydrochloric acid solution (20 mL, 240 mmol) was added dropwise over 10 min via addition funnel resulting in the formation of a tan precipitate. The mixture was allowed to warm to 25° C. and was stirred at that temperature for 21 h. The precipitate was collected by filtration, washed with water (150 mL), and was dried in a vacuum oven at 45° C. for 22 h to afford (7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-acetic acid (18.36 g, 55.1 mmol, 93% yield) as a tan solid. 1H NMR (400 MHz, DMSO-d6) δ: 3.03 (3H, s), 3.56 (2H, s), 7.32-7.34 (1H, m), 7.51-7.54 (2H, m), 10.09 (1H, s), 12.26 (1H, s), 13.01 (1H, bs). LC-MS (ESI) calcd for C10H11N3O6S2 333.01. found 334.1 [M+H+].
Workup
- temperaturewas gradually cooled over 30 min to 0° C
- customresulting in the formation of a tan precipitate
- temperatureto warm to 25° C.
- filtrationThe precipitate was collected by filtration
- washwashed with water (150 mL)
- customwas dried in a vacuum oven at 45° C. for 22 h
Sources & evidence
- ORD record
- ord-6a398a69ae824ffe84348ff960c9c5c5
- Source dataset
- uspto-grants-2010_11
- Patent number
- US07842838B2
Reaction notes
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