Ammonium Hydroxide → HCID 178480466, compound

HRID 1177162Notes

Reaction equation

HRID 1177162 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([C:10]2[CH:20]=[C:19]([O:21][C:22]3[CH:23]=[N:24][C:25]([C:28]#[N:29])=[CH:26][CH:27]=3)[C:13]3[CH2:14][C:15]([CH3:18])([CH3:17])[O:16][C:12]=3[CH:11]=2)=[O:9])=[N:3]1.[NH4+:30].[OH-:31]>CCO.O>[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([C:10]2[CH:20]=[C:19]([O:21][C:22]3[CH:23]=[N:24][C:25]([C:28](=[NH:30])[NH:29][OH:31])=[CH:26][CH:27]=3)[C:13]3[CH2:14][C:15]([CH3:18])([CH3:17])[O:16][C:12]=3[CH:11]=2)=[O:9])=[N:3]1

Participants

5

Reactant 2

HCID 14923Ammonium HydroxideHCID 667561004-(6-Cyano-pyridin-3-yloxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide

Product 1

HCID 178480466HCID 178480466, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 4-(6-cyano-pyridin-3-yloxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide (181) in 3 mL EtOH was added 1 mL 50% NH4OH in water. The resulting mixture was stirred at room temperature for 2 hr, concentrated in vacuo, dried under vacuum, and used as it is for the next step.

Workup

  1. concentrationconcentrated in vacuo
  2. customdried under vacuum

Sources & evidence

ORD record
ord-7f370a53192c47faa218a3ce67211c1b
Source dataset
uspto-grants-2010_11
Patent number
US07842713B2

Reaction notes

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