反应详情

温度

25 °C

To a suspension of (2-(4-(1,3-dioxan-2-yl)-2-fluorophenyl)thiazolo[5,4-b]pyridine-5-yl)(phenyl)methanone (718.0 mg, 1708 μmol) in methanol (12.0 mL) and THF (4.8 mL) was added sodium borohydride (64.6 mg, 1708 μmol), and the resulting solution was stirred at 25° C. for 10 min. Saturated aqueous NH4Cl (10 mL) was then added, and MeOH and THF were removed in vacuo. The resulting suspension was partitioned between ethyl acetate and water). The organic layer was separated and washed with brine, and the aqueous layer was extracted with EtOAc. The combined organic extracts were dried over sodium sulfate, filtered, and concentrated in vacuo to provide (2-(4-(1,3-dioxan-2-yl)-2-fluorophenyl)thiazolo[5,4-b]pyridine-5-yl)(phenyl)methanol as a yellow solid. MS (ESI) m/z: Calculated: 422.1; Observed: 423.0 (M++1).

1. customMeOH and THF were removed in vacuo
2. customThe resulting suspension was partitioned between ethyl acetate and water)
3. customThe organic layer was separated
4. washwashed with brine
5. extractionthe aqueous layer was extracted with EtOAc
6. dry with materialThe combined organic extracts were dried over sodium sulfate
7. filtrationfiltered
8. concentrationconcentrated in vacuo