HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3-Benzothiadiazole → 3-Methyl-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3-Benzothiadiazole | HCID 67505 | — |
| Reactant | 4-Bromo-3-methylbenzonitrile | HCID 2737494 | — |
| Reactant | 5-(1-Phenylcyclopropyl)thiazolo[5,4-b]pyridine | HCID 59174874 | — |
| Product | 3-Methyl-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)benzonitrile | HCID 67111682 | — |
Reaction Steps
3-Methyl-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)benzonitrile was synthesized from 5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine (48.3 mg, 191 μmol) and 4-bromo-3-methylbenzonitrile (45.0 mg, 230 μmol) according to Reference T and the general procedure for azabenzothiazole 2-arylation as a light yellow solid. MS (ESI) m/z: Calculated: 367.1; Observed: 368.1 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-1e3cbe31eb4f44c8a91e1022abf70cea |
| Source note | uspto-grants-2010_11 |