反应详情

A slurry of N-(4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)-1-hydroxy-2-(hydroxymethyl)butan-2-yl)acetamide (0.205 g, 0.405 mmol) in 6 mL 5N aq. HCl was heated to 120° C. in a sealed tube. A clear yellow solution resulted, with a white precipitate forming after 1 h. The mixture was heated overnight to give a gray mixture, which was cooled and filtered through a glass frit, rinsing with water and EtOH, and the solid was dried in vacuo to give 2-amino-2-(2-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)ethyl)propane-1,3-diol hydrochloride as an off-white solid. MS (ESI) m/z: calculated: 463.2; Observed: 464.1 (M++1).

1. customA clear yellow solution resulted, with a white precipitate
2. customforming after 1 h
3. temperatureThe mixture was heated overnight
4. customto give a gray mixture, which
5. temperaturewas cooled
6. filtrationfiltered through a glass frit
7. washrinsing with water and EtOH
8. customthe solid was dried in vacuo