HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluorobenzaldehyde → 2-(4-Bromo-2-fluorophenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluorobenzaldehyde | HCID 143517 | — |
| Reactant | 3-Aminopyridine-2-thiol | HCID 5463181 | — |
| Reactant | 3-amino-6-(1-phenylcyclopropyl)pyridine-2(1H)-thione | HCID 59174836 | — |
| Product | 2-(4-Bromo-2-fluorophenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine | HCID 67111999 | — |
Reaction Steps
Reaction of 3-amino-6-(1-phenylcyclopropyl)pyridine-2(1H)-thione (50.0 mg, 206 μmol) and 4-bromo-2-fluorobenzaldehyde (44.0 mg, 217 μmol) according to Reference U and the general procedure for oxidative condensation of 3-aminopyridine-2-thione with aryl aldehydes gave 2-(4-bromo-2-fluorophenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine as a light yellow solid. MS (ESI) m/z: Calculated: 424.0; Observed: 424.9 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-9cb93cc2bc0d422e912b6bad67240fc1 |
| Source note | uspto-grants-2010_11 |