HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Difluorobenzoyl chloride → 2-(2,4-Difluorophenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Difluorobenzoyl chloride | HCID 588081 | — |
| Reactant | 3-Aminopyridine-2-thiol | HCID 5463181 | — |
| Reactant | 3-amino-6-(1-phenylcyclopropyl)pyridine-2(1H)-thione | HCID 59174836 | — |
| Product | 2-(2,4-Difluorophenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine | HCID 67111790 | — |
Reaction Steps
Reaction of 3-amino-6-(1-phenylcyclopropyl)pyridine-2(1H)-thione (27.3 mg, 113 μmol) and 2,4-difluorobenzoyl chloride (13.8 μl, 113 μmol) according to Reference V and the general procedure for the condensation of 3-aminopyridine-2-thione with aryl acid chlorides to give 2-(2,4-difluorophenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine as a white solid. MS (ESI) m/z: Calculated: 364.1; Observed: 365.0 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-2a5069a366d349ab80b80547625e2a15 |
| Source note | uspto-grants-2010_11 |