HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzaldehyde → 2-(4-Fluorophenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzaldehyde | HCID 68023 | — |
| Reactant | 3-Aminopyridine-2-thiol | HCID 5463181 | — |
| Reactant | 3-amino-6-(1-phenylcyclopropyl)pyridine-2(1H)-thione | HCID 59174836 | — |
| Product | 2-(4-Fluorophenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine | HCID 67111618 | — |
Reaction Steps
Reaction of 3-amino-6-(1-phenylcyclopropyl)pyridine-2(1H)-thione (52.6 mg, 0.217 mmol) and 4-fluorobenzaldehyde (22 μl, 0.206 mmol) according to Reference V and the general procedure for the condensation of 3-aminopyridine-2-thione with aryl acid chlorides gave 2-(4-fluorophenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine as a white solid. MS (ESI) m/z: Calculated: 346.1; Observed: 347.1 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-efefcf12d342424c90e9b4ad158cc81b |
| Source note | uspto-grants-2010_11 |