HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1177610Generated: November 4, 2026
Hydrochloric Acid → 4-(3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)butanoic acid
https://huagongshe.com/reaction/1177610
Participants
| Role | Name | HCID | Charge |
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| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl 2-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenethyl)malonate | HCID 67111704 | — |
| Product | 4-(3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)butanoic acid | HCID 44600484 | — |
Reaction Steps
In reactor bottle, hydrochloric acid, 5N aq. (3 mL) was added to diethyl 2-(2-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)ethyl)malonate (0.257 g, 0.48 mmol), and the mixture heated to 120° C. for 6 h. The crude reaction mixture was concentrated in vacuo and purified by silica gel chromatography to afford 4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)butanoic acid. MS (ESI) m/z: calculated: 432.1; Observed: 433.0 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07842685B2 |
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| Source dataset | uspto-grants-2010_11 |
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| ORD ID | ord-f0818982d1fa4a8091c738c4baff3f4c |
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| Source note | uspto-grants-2010_11 |
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