反应详情

温度

120 °C

In reactor bottle, hydrochloric acid, 5N aq. (3 mL) was added to diethyl 2-(2-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)ethyl)malonate (0.257 g, 0.48 mmol), and the mixture heated to 120° C. for 6 h. The crude reaction mixture was concentrated in vacuo and purified by silica gel chromatography to afford 4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)butanoic acid. MS (ESI) m/z: calculated: 432.1; Observed: 433.0 (M++1).

1. customThe crude reaction mixture
2. concentrationwas concentrated in vacuo
3. custompurified by silica gel chromatography