(2-Methoxyethyl)(methyl)amine → 3-fluoro-N-(2-methoxyethyl)-N-methyl-4-(5-(1-phenylcyclopropyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl)benzamide
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]1[S:12][C:13]2[C:18]([N:19]=1)=[CH:17][CH:16]=[C:15]([C:20]1([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:22][CH2:21]1)[N:14]=2)[C:5](O)=[O:6].[CH3:29][O:30][CH2:31][CH2:32][NH:33][CH3:34]>>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]1[S:12][C:13]2[C:18]([N:19]=1)=[CH:17][CH:16]=[C:15]([C:20]1([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:21][CH2:22]1)[N:14]=2)[C:5]([N:33]([CH2:32][CH2:31][O:30][CH3:29])[CH3:34])=[O:6]Participants
3
Procedure
The title compound was synthesized using the procedure described in Example 105 above, with 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzoic acid (93 mg, 0.238 mmol) and N-(2-methoxyethyl)methylamine (31 μl, 0.286 mmol). MS (ESI) m/z: Calculated: 461.2; Observed: 462.1 (M++1).
Sources & evidence
- ORD record
- ord-355c112b93a34be0bde7e82c9eeae8eb
- Source dataset
- uspto-grants-2010_11
- Patent number
- US07842685B2
Reaction notes
Loading…