反应详情

To 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzenamine (34 mg, 0.094 mmol) was added DCM (0.9 mL), triethylamine (26 μl, 0.188 mmol), and methanesulfonyl chloride (11 μl, 0.141 mmol) before it was stirred at ambient T for 1 h. The reaction mixture was diluted with 100 mL of DCM, added to a separatory funnel, partitioned with 5 N NaOH (aqueous), washed 3 times with 75 mL of 5 N NaOH (aqueous), separated, dried over sodium sulfate, and concentrated via rotovap to the title compound. MS (ESI) m/z: Calculated: 517.1; Observed: 518.0 (M++1).

1. additionadded to a separatory funnel
2. custompartitioned with 5 N NaOH (aqueous)
3. washwashed 3 times with 75 mL of 5 N NaOH (aqueous)
4. customseparated
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated via rotovap to the title compound