Hydrochloric Acid → HCID 178525798, compound

Participants

Reaction Steps

Methyl cis-3-((3-fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)amino)cyclobutanecarboxylate (2.0 mg, 4.2 μmol) was dissolved in THF (42 μl) before 0.1 N sodium hydroxide (42 μl, 4.2 μmol) was added and stirred at ambient temperature for 16 h. The reaction mixture was acidified with 2 N HCl, diluted with THF, separated, dried over sodium sulfate, and was concentrated to give the title compound. MS (ESI) m/z: Calculated: 459.1; Observed: 460.0 (M++H).

Provenance & Evidence