HRID1177640

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID14798

Sodium Hydroxide

HNaO

结构：COC(=O)[C@H]1C[C@@H](Nc2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)C1

HCID178501321

未命名化合物

PRODUCTS

生成物

结构：O=C(O)[C@H]1C[C@@H](Nc2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)C1

HCID178525798

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

2 次

PROCEDURE

实验过程

Methyl cis-3-((3-fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)amino)cyclobutanecarboxylate (2.0 mg, 4.2 μmol) was dissolved in THF (42 μl) before 0.1 N sodium hydroxide (42 μl, 4.2 μmol) was added and stirred at ambient temperature for 16 h. The reaction mixture was acidified with 2 N HCl, diluted with THF, separated, dried over sodium sulfate, and was concentrated to give the title compound. MS (ESI) m/z: Calculated: 459.1; Observed: 460.0 (M++H).

WORKUP

后处理

additionwas added
customseparated
dry with materialdried over sodium sulfate
concentrationwas concentrated