反应详情

2-(Isoindolin-5-yl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine (75 mg, 0.203 mmol) was dissolved in methanol (2.0 mL) and DCM (1 mL) before ethyl acrylate (27.1 μL, 0.244 mmol) and 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine (1.457 μL, 10.15 μmol) were added and stirred at ambient temperature for 16 h. Methyl 3-(5-(5-(1-phenylcyclopropyl)-thiazolo[5,4-b]pyridin-2-yl)isoindolin-2-yl)propanoate was obtained after purification via flash chromatography. MS (ESI) m/z: Calculated: 455.2; Observed: 456.4 (M++H).