Water → 4-Bromo-2-ethyl-6-methylaniline

HRID 1177701노트

반응식

HRID 1177701 반응식
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:4]=1[NH2:10])[CH3:2].O.[Br:12]Br>Cl>[Br:12][C:7]1[CH:6]=[C:5]([CH3:9])[C:4]([NH2:10])=[C:3]([CH2:1][CH3:2])[CH:8]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24408BromineHCID 324852-Ethyl-6-methylaniline

생성물 1

HCID 9607614-Bromo-2-ethyl-6-methylaniline

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

2-Ethyl-6-methyl-phenylamine (14 mL, 100 mmol) was dissolved in concentrated hydrochloric acid (30 mL) and water (220 mL) and cooled to 0° C. To this was added bromine (5.1 mL, 1 equiv.) dropwise. There was rapid formation of a white precipitate. The precipitate was filtered and washed with diethyl ether. The precipitate was suspended in water and neutralized with aqueous potassium carbonate. An oil formed which was extracted into diethyl ether. The ethereal was dried over potassium carbonate, filtered, and concentrated to give 7.0 g (33%) as a purple oil which was used without purification. Mass spec.: 214.01 (MH)+.

후처리

  1. filtrationThe precipitate was filtered
  2. washwashed with diethyl ether
  3. customAn oil formed which
  4. extractionwas extracted into diethyl ether
  5. dry with materialThe ethereal was dried over potassium carbonate
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customto give 7.0 g (33%) as a purple oil which
  9. customwas used without purification

출처 및 근거

ORD 기록
ord-8a4e7219158549a3b9555c440eab15a6
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07842808B2

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