Dichloromethane → 3-[(4-Chloro-2,6-difluorophenyl)(cyclopropyl)methyl]-5-fluoro-7-[(methylsulfonyl)methyl]-1H-indole
Reaction equation
[Cl:1][c:2]1[cH:3][c:4]([F:14])[c:5]([CH:9]([OH:10])[CH:11]2[CH2:12][CH2:13]2)[c:6]([F:8])[cH:7]1.[Cl:37][CH2:38][Cl:39].[F:22][c:23]1[cH:24][c:25]2[cH:26][cH:27][nH:28][c:29]2[c:30]([CH2:32][S:33](=[O:34])(=[O:35])[CH3:36])[cH:31]1.[OH:15][C:16]([C:17]([F:18])([F:19])[F:20])=[O:21]>>[Cl:1][c:2]1[cH:3][c:4]([F:14])[c:5]([CH:9]([CH:11]2[CH2:12][CH2:13]2)[c:26]2[c:25]3[cH:24][c:23]([F:22])[cH:31][c:30]([CH2:32][S:33](=[O:34])(=[O:35])[CH3:36])[c:29]3[nH:28][cH:27]2)[c:6]([F:8])[cH:7]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-1a35f3c3531f4d48bf71097c28fd5484
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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