Hydrogen Bromide → 1-(Bromomethyl)-2-(trifluoromethyl)benzene
Reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9]O.[BrH:13]>O>[Br:13][CH2:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:12])([F:11])[F:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
A mixture of (2-trifluoromethyl-phenyl)-methanol (100 mg, 0.57 mmol) and HBr (0.6 mL) was stirred at 0° C. for 2 hours then at 60° C. for 3 hours. Water was then added, and the product extracted with EtOAc. The organic layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure to afford 1-bromomethyl-2-trifluoromethyl-benzene in 55% yield.
Workup
- waitat 60° C. for 3 hours
- extractionthe product extracted with EtOAc
- washThe organic layer was washed with brine
- dry with materialdried over Na2SO4
- concentrationconcentrated under reduced pressure
Sources & evidence
- ORD record
- ord-19e9cd79bd5b4ff0a74417f62b3f6678
- Source dataset
- uspto-grants-2010_11
- Patent number
- US07842696B2
Reaction notes
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