Hydrochloric Acid → 4-phenyl-1H-pyrazole hydrochloride

HRID 1178108Notes

Reaction equation

HRID 1178108 reaction equation
[C:1]1([C:7]2[CH:8]=[N:9][N:10](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:31]>CCOCC>[ClH:31].[C:1]1([C:7]2[CH:8]=[N:9][NH:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 595596204-Phenyl-1-(triphenylmethyl)-1H-pyrazole

Product 1

HCID 665923304-phenyl-1H-pyrazole hydrochlorideYield 93.61%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 4-phenyl-1-trityl-1H-pyrazole (120 mg, 0.33 mmol) in Ether.HCl (10 mL) was stirred for 1 hr. The reaction mixture was then concentrated under reduced pressure to afford the residue. The residue obtained was washed with hexane to afford 44 mg (93.61%) of 4-phenyl-1H-pyrazole hydrochloride salt. 1H NMR (DMSO-d6): δ 8.1-8.08 (s, 2H), 7.64 (d, 2H), 7.38 (t, 2H), 7.22 (t, 1H).

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. customto afford the residue
  3. customThe residue obtained
  4. washwas washed with hexane

Sources & evidence

ORD record
ord-e11280c59b4949de95b3b387c264466f
Source dataset
uspto-grants-2010_11
Patent number
US07842696B2

Reaction notes

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